An imbalance of bacteria within our gut microbiome. Dysbiosis occurs when there is an imbalance between us (the human host) and our microbiome64 .
Endotoxins are part of the cell wall of
Gram negative bacteria65 . Often referred to
in relation to leaky gut, bacterial-derived lipopolysaccharides (LPS), are an example of an endotoxin that is able to pass through the gut lining and into the bloodstream. In the case of leaky gut, these endotoxins may contribute to low-grade system inflammation.
When there is an optimal balance of bacteria in our gut, this is known as eubiosis66 .
When it comes to our gut microbes, diversity is a very good thing. We want a good balance of beneficial, pathogenic and indifferent bacteria to experience optimal health and wellbeing. To foster microbial diversity, a nutrient-balanced diet including lots of fibre and wholefoods is key to providing an ideal environment for a variety of bacteria.
Plant compounds found in a variety of wholefoods and spices that may exhibit
anti-inflammatory benefits67 .
SHORT-CHAIN FATTY ACIDS
Short-chain fatty acids are anti-inflammatory compounds which are produced when dietary fibre is fermented in the colon. Examples include acetate, propionate and butyrate – which may benefit gut health. Butyrate helps to improve intestinal barrier function, reduce inflammation, assists with intestinal motility, immune regulation and iron absorption68,69,70 . Consuming fibre-rich fruits and vegetables which may help to encourage the production of short-chain fatty acids.
The presence of both probiotics and prebiotics – working synergistically together71.